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IONS· Ionis Pharmaceuticals Inc.

CUSIP 462222100·Sector Healthcare··Investor Relations
Current price
$75.71
Market cap
$12.5B
52w low
$32.00
52w high
$86.74
Whale holders
1
Aggregate held
$171M
Net flow (Q/Q)
-$24M
Insider buys/sells · last 6 mo · open market only
TransactionsTotal $
Buys0$0
Sells0$0
Whale% of portfolioRecent activityΔ sharesValue
Tweedy, Browne Co. LLC13.6%Reduce 7.7%-189,305$171M
Quarterly ownership history
Last 6 quarters
QuarterWhalesAggregateBuyingSellingNet flow
2026-03-311$171M0 · $01 · $24M-$24M
2025-12-311$195M1 · $5M0 · $0$5M
2025-09-301$190M1 · $76M0 · $0$76M
2025-06-301$114M1 · $24M0 · $0$24M
2025-03-311$90M1 · $90M0 · $0$90M
2024-12-313$36M3 · $36M0 · $0$36M
IONS Financials
Live via yfinance — refreshed daily.
Valuation
Market capitalization$12.5B
Enterprise value$13.1B
EV / EBITDA (TTM)-38.81
P/E ratio (TTM)
Forward P/E-122.13
P/S ratio11.82
P/B ratio25.56
PEG ratio
Cash Flow
Operating cash flow (TTM)-$911M
Free cash flow (TTM)-$808M
Total cash$2.0B
Total debt$2.6B
Debt / equity531.05
Current ratio4.10
Income Statement
Total revenue (TTM)$1.1B
Revenue per share (TTM)6.55
Gross profit (TTM)$116M
EBITDA (TTM)-$339M
Net income (TTM)-$327M
EPS diluted (TTM)-2.01
Shares outstanding165,262,556
Float shares163,980,119
Profitability
Gross margin10.94%
Operating margin-47.72%
EBITDA margin-32.00%
Net margin-30.90%
Efficiency
Return on assets (TTM)-7.03%
Return on equity (TTM)-67.62%
Price History
Current price$75.71
52 Week high$86.74
52 Week low$32.00
50 day average$74.60
200 day average$70.54
Average volume (10 day)2,051,630
1-year beta0.38
1-year price target$100.74
Dividends
Dividend yield
Dividend rate (annual)
Payout ratio0.00%
Fundamentals are sourced from yfinance and refreshed daily. Last updated May 10, 2026, 5:38 PM. Empty cells (—) mean yfinance doesn't have that field for this ticker (common for ADRs, recent IPOs, or non-applicable ratios).
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